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Shared epigenetic mechanisms in depression-drug addiction comorbidity To better integrate these findings, we introduce a unifying three-axis framework, stress-response regulation, reward-circuit remodeling, and synaptic plasticity, which provides a coherent structure for understanding how epigenetic alterations converge across depression, drug addiction, and drug addiction-induced depression

Yin W, Wang C, Peng Y et al (2020) Dexmedetomidine alleviates H 2 O 2 -induced oxidative stress and cell necroptosis through activating of 2-adrenoceptor in H9C2 cells

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As a critical link between extracellular signals and intracellular autophagic activity, this pathway precisely controls the initiation and progression of autophagy by integrating signals such as growth factors, nutrient availability, and energy status

The powder should dissolve gradually as water runs down the wall

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