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Moreover, MAPs regulated proteins related to apoptosis, such as the expression of Bcl-2, Bax, caspase-3, and caspase-9 ( Astragalus mongholicus Bunge polysaccharides (APS) also repressed apoptosis by enhancing Bcl-2 levels and diminished Bax, caspase-3, and caspase-9 levels (Sun et al., 2019)

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While viral vectors offer high efficiency, their immunogenicity and limited cargo capacity pose notable drawbacks

Accordingly, the incidence of CIPN approaches nearly 100% for some agents at higher doses (Seretny et al., 2014), although differences in the definition, evaluation and reporting of peripheral neuronal deficits can lead to large variability in the reported occurrence

The most well-studied role of SFN is its action on the KEAP1-NRF2 pathway

189 Among the various Cu chelators developed to date, TTM has been well-studied in several models