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Structurally, XO comprises a molybdopterin unit containing an Mo atom

Using serine verses glycine (or glutathione) also supports one carbon metabolism in its metabolic journey to glycine

Luo Y, Xie Y, Li W, Wei M, Dai T, Li Z, Wang B (2021) Physiological and transcriptomic analyses reveal exogenous trehalose is involved in the responses of wheat roots to high temperature stress

Importantly, the dose of ferrous iron sulfate used in these studies was 0.15 mmol/kg FeSO 4 (human equivalent dose: 1.85 mg/kg), which is less than the recommended dose for an iron supplement (1 tablet with 325 mg FeSO 4 = 5.4 mg/kg)

It is not obvious that the methionine cycle would need to be supported by a biochemical like glutathione, whose formation is considered to be dependent on the function of the methionine cycle

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