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Certain mycotoxins are fatloving and can be stored in body fat, then recycled through the livergut loop (enterohepatic recirculation), prolonging symptoms long after leaving a moldy environment

Dr Shah-Desai outlines them below: Niacinamide "Niacinamide is a powerful antioxidant that enhances the prevention of pigmentation, improves the lightening effect on brown spots, and works in synergy with tranexamic acid for visible improvements of dark circles." Vitamin C "A stabilised form of vitamin C will help provide powerful antioxidant benefits and also delivers a brightening effect on pigmentation and dark spots." Caffeine "In addition to providing antioxidant benefits, caffeine is a vasoconstrictor and can provide a shrinking effect on the diameter of blood vessels, which in turn can lead to a decrease in dark circles, fine lines and puffiness around the eyes." Tranexamic Acid "Tranexamic acid inhibits UV-induced melanin synthesis by blocking the interaction between keratinocytes and melanocytes and ensures that long term accumulative results are not compromised by UV exposure." Natural Arbutin "This ingredient strongly inhibits tyrosinase activity, which is the key enzyme of the pigmentation process

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Its not a panacea, Hu says

doi: 10.1016/S0928-4257(00)00148-0