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Maintaining the balance in bilirubin metabolism and excretion is crucial, as disturbances can lead to pathological conditions, including gallstone formation, due to altered bilirubin handling and metabolism

NADPH oxidase 4 (Nox4) suppresses mitochondrial biogenesis and bioenergetics in lung fibroblasts via a nuclear factor erythroid-derived 2-like 2 (Nrf2)-dependent pathway

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Collectively, these findings establish a novel mechanistic link between AIBP and hepatic lipid homeostasis, wherein AIBP deficiency exacerbates metabolic dysregulation and inflammation through ITG3-dependent PI3K/AKT pathway activation