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74 PLC1 catalyzes the synthesis of diester glycerol and inositol (1,4,5)-trisphosphate as second messengers that trigger mitogen-activated protein kinase, protein kinase C (PKC) and calmodulin phosphatase

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However, cancer cells can escape cellular ferroptosis by activating or remodeling various signaling pathways, including oxidative stress pathways, thereby limiting the efficacy of ferroptosis-activating targeted therapy

Results may be reported as wild type, heterozygous, homozygous, or compound heterozygous

Methods: H69 cholangiocytes, THP1 monocyte cell line and cholangiopathy mouse model (0.1% diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate [DDC] diet feeding x14d) were used

Statistical methods All statistical analyses were performed, and all data figures were created using PRISM GraphPad version 9.1.2 (La Jolla, USA) unless otherwise specified