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5.3.4 Methyl Transferases While glucuronidation, glutathionation, sulfonylation, as well as several other Phase II metabolism pathways increase the water-solubility of drugs, processes such as methylation (and acetylation below) do not substantially alter values such as LogP

Stangel-Wjcikiewicz K, Murawski M, Schwarz T, Skotniczny K, Fuchs A, Wolski J, et al

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Nucleic acids research 33 , 68846894, doi:10.1093/nar/gki1000 (2005)

Glutathione is generally well-tolerated with minimal side effects