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Without enough reduced glutathione to neutralize these byproducts, the immune cells can become sluggish

63 Other SOD mimetics such as the manganese metaloporphyrin AEOL-10113 decrease murine airway inflammation and hyperreactivity, 64 whereas AEOL-10150 decreases cigarette smoke-induced pulmonary inflammation

Previous work has reported relatively increased Firmicutes and Proteobacteria and decreased Bacteroidetes in mice on an HFD, regardless of concomitant obesity (weight gain was minimized using a RELM knockout mouse 78 ) 78,79