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If Kennedy justifies reversal of the previous work by suggesting there were no safety concerns, it would give a false imprimatur of safety to more than a dozen unapproved, untested drugs, the officials said

In contrast, FOXO4-DRI leverages the elevated expression of FOXO4 and P53 in senescent cells by specifically blocking the interaction between FOXO4 and P53 to promote apoptosis via the P53 signaling pathway (Tao et al., 2016