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8A), subsequently, increased activity of POX and CAT (Fig

AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system Xc(-) activity

This can be especially beneficial for lupus patients who have not responded well to standard treatments or for those who cannot tolerate these medications due to side effects

Specifically, the Akt signal pathway directly acts on FoxO3a to reduce its expression, further inhibiting production of autophagy marker LC3B on the collagen matrix, leading to excessive collagen accumulation (Im et al., 2015)

This effect was observed by Yang et al