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Metabolic orchestration driven by GGCT: diverting glutamine to glutathione biosynthesis while enhancing glucose anaplerosis for tumor proliferation Cell Death & Disease Glutaredoxin catalysis requires two distinct glutathione interaction sites Nature Communications Glutathione Synthesis in Cancer Cells Biochemistry (Moscow) Springer Nature Link Long noncoding RNA GDIL acts as a scaffold for CHAC1 and XRN2 to promote platinum resistance of colorectal cancer through inhibition of glutathione degradation Cell Death & Disease Catabolism of extracellular glutathione supplies cysteine to support tumours Nature Multi Omics Analysis Reveals Chronic Cisplatin Exposure Is Associated with Metabolic Rewiring Toward Glutathione Metabolism to Support Redox Adaptation in High Grade Serous Ovarian Cancer

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It holds this title because it is found in high concentrations in nearly every cell

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3, 2021 [7] A

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