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In Gstp1/2 / mice, basal level of Caspase 3 activity was significantly higher than in the WT normal livers, and this activity did not show any increase over the time course performed

Furthermore, the GRAPE formula ( Panax ginseng , Rehmannia glutinosa , Acorus tatarinowii , Yuan Zhi , and Epimedium brevicornu ) showed sustained cognitive improvements in dementia patients, surpassing conventional therapies over a 24-month period (Shi et al., 2017)

Limitations of current evidence include small sample sizes, short study durations, heterogeneous patient populations, and varying dosing regimens

Therefore, statistical summaries were not planned for this review

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Acknowledgements The authors acknowledge the Department of Biotechnology and Microbiology, School of Sciences, Noida International University, Gautam Budh Nagar, U.P., India for the required facilities