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HBV+HDV/ HCV etiology=63%, Autoimmune (AILD)=15%, ASH/cryptogenic/other=22%

As a control amino acid of kynurenine metabolism, tryptophan (0.1, 1, and 10), which was neither accumulated in SLE nor influenced by NAC, did not stimulate mTOR activity (data not shown)

Our group has developed a GDEPT system that uses the bacterial enzyme carboxypeptidase G2 to convert nitrogen mustard prodrugs into potent DNA crosslinking agents, and a clinical trial of this system is pending