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The copper ion binds to the peptide through a square-planar pyramid configuration, creating an extraordinarily stable complex with a binding affinity (pK = 16.44) approximately 10 million times higher than other tripeptides

Meanwhile, the roles of GH and IGF1 are influenced by GH-binding proteins (GHBPs) and IGF-binding proteins (IGFBPs), respectively (Duan and Xu, 2005)

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doi: 10.1111/j.1365-3164.2006.00551.x