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D14 requires the F-box protein MAX2 (MORE AXILLARY GROWTH2) as the SL signal-transducing component, and MAX2 is also required for KAR signaling 21,22,23,24,25

doi: 10.1016/j.phymed.2022.154615 Summary Keywords Scrophulariae Radix , endocrine disorders, thyroid diseases, diabetes mellitus, pharmacological effects, mechanisms Citation Song J, Li J, Shi H, Liu H, Qu Y and Wang F (2025) The mechanism and application of Scrophulariae Radix in the treatment of endocrine disorders: focusing on thyroid diseases and diabetes mellitus

Results We demonstrated that this peptide-liposome-small molecule machinery targets AML and consequently induces cell apoptosis both in vitro and in vivo through three disparate mechanisms: (I) Oridonin, as a Michael acceptor molecule, inhibits GSH function through covalent bonding, triggering an initial imbalance of oxidative stress

[Abstract]2023 Dec 13;10(1):e23506

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Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection