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4.2 Inherent deficiencies of glutamine metabolism inhibitors Many reported glutamine metabolism inhibitors have shown serious off-target effects

Both dietary patterns negatively affected the intestinal microbiota and increased intestinal permeability [34]

Referncias Askarpour M, Hadi A, Miraghajani M, Symonds ME, Sheikhi A, Ghaedi E

In prostate tumors, the PCGEM1 lncRNA promotes the expression of GLUT1

Reportedly, glutamate is involved in maladaptive neuroplastic processes contributing to generation and maintenance of pain and mood disorders (Riggs and Gould, 2021)

Acknowledgements This study was supported by Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES), Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq) and Fundo de Incentivo Pesquisa e Eventos (FIPE/HCPA)