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Therefore, further clinical trials are necessary to validate their therapeutic efficacy

Genetic variants influencing drug metabolism can facilitate the selection of pharmacological treatments, improving efficacy and reducing adverse effects

Current evidence supports the use of systemic antioxidants for management of selected cases of male infertility [175]

In the 11 patients who reproduced their typical symptoms upon challenge testing, hyperventilation was induced in every case, with a rapid fall in the pCO 2 in blood and no change or a rise in pO 2 or SaO 2 , while pulmonary function remained unchanged