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HERA 48 was performed by seeding HMEC-1-FcRn cells (1.5 10 5 cells/well) to a Costar 48-well TC-Treated Multiple Well Plate (Corning) in complete culture medium (250 L/well) for approximately 2024 h until confluent

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Longer studies are needed

Remarkably, beneficial effects have been observed across this 100-fold range, suggesting a wide therapeutic window where smaller doses remain biologically active