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After 3-4 years, you can re-assess the situation to see if life-long thyroxine is necessary

Nutrients 12(6):1562

Furthermore, investigations into microbial therapeutic approaches, such as fecal microbiota transplantation, have gained ground due to studies suggesting that bacterial transfers from depressed individuals to germ-free animals produce similar adverse behavioral outcomes [242,243]

[1] [2] The medication works by mimicking incretin hormones that regulate appetite, slow gastric emptying, and enhance insulin secretion while suppressing glucagon release