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Excessive extracellular glutamate concentration blocks the uptake of CySS which is essential for biosynthesis of GSH

Regarding P38 activation, similar profiles were obtained in WT and Gstp1/2 / mice

Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery

Trichinella spiralis infection has been shown to induce inhibition of HCT-8 colorectal carcinoma in BALB/c mice as demonstrated by a decrease in size and weight of tumors [80]

J Clin Hypertension

Lithocholic acid, in particular, is cytotoxic if present at high concentrations, and physiologic mechanisms have developed to limit its toxicity, particularly in the bile ductules, as will be described in more detail later