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Follow on studies include demontration of its efficacy and safety in the pediatric population (BABY HUG) (Wang et al., 2011), the Transcranial doppler with Transfusion Changing to Hydroxyurea Study (TWiTCH) that showed HU was comparable to blood transfusions for primary stroke prevention (Ware et al., 2016) although the Stroke with Transfusion Changing to Hydroxyurea study (SWiTCH) concluded that HU is not comparable to blood transfusion in secondary stroke prevention (Ware et al., 2011)

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3.8 Berberine Berberine is an isoquinoline alkaloid found in some plants like goldenseal, goldthread and Oregon grape

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In addition, the pH of the solution does not change significantly with the extension of reaction duration, indicating no obvious hydrolysis of Cu 2+ (Fig