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The simulations suggested that quinone metabolism yielded an increase in ROS (O 2 . and H 2 O 2 ), producing a maximum of 0.42 M and 1 10 3 M respectively

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Whether the composition of microbiota in human body might also have a role in the cytotoxic effects of thiopurines is still questioned [37]

doi: 10.1001/jamanetworkopen.2020.19722 42 MessikaJ.SztrymfB.BertrandF.Billard-PomaresT.BarnaudG.BrangerC.et al