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Federici, T

Mann, J

Drug Metab Rev (2013) 45:15663

More metabolic parameters, such as fumarate, -KG, GLUT1, glycolytic enzymes (e.g., PKM2, hexokinase, pyruvate dehydrogenase), FAS-associated enzymes (e.g., fatty acid synthase, acetyl-CoA carboxylase), and other amino acids (e.g., tryptophan, methionine), also undergo significant alteration in the metabolic adaptation of macrophages [24, 303,304,305,306] and can serve as theoretical targets for innovative therapies

Based on the need for transfusion therapy, -thal can be classified as transfusion-dependent -thal (TDT) and non-transfusion-dependent -thal (NTDT) (Crisponi et al., 2019)

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