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Iron Overload Resulting from the Chronic Oral Administration of Ferric Citrate Impairs Intestinal Immune and Barrier in Mice

Their study also confirmed that p62 mediates the degradation of Keap1, as evidenced by in vitro experiments involving p62 knockdown with siRNAs [133]

doi: 10.1038/s41419-022-04912-8 42 YangWSKimKJGaschlerMMPatelMShchepinovMSStockwellBR

Zawrotniak, M., Kozik, A

There could be back-up systems whereby reactive oxygen species would be attacked by 1 antioxidant as a first line of defense, with escaping molecules handled by a second collection of antioxidants