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Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1

Cytochrome P450 2E1 and its roles in disease

Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death

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Satellite cells (SCs), which are located under the basal layer of muscle fiber, are critical for skeletal muscle regeneration, maintaining a reversible static state and activating myoblasts when needed

However, possible side effects include nausea, headache, muscle cramps, or chest tightness during or shortly after the infusion