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These studies collectively underscore that precise manipulation of microbial BA metabolic pathways, whether by enhancing beneficial BA production or inhibiting detrimental BA formation, can significantly impact host immune homeostasis and disease progression

[DOI] [Google Scholar] 274.Iqbal S., Ali Q., Malik A

Consequently, a study found that immune cells were prone to the effects of lipid peroxidation by ROS due to the polyunsaturated fatty acids present in their cell membranes (179, 180)

Specifically, FOXO4-DRI peptide has been researched as a decoy that may compete with FOXO4 for p53 binding, so it may disrupt the FOXO4p53 interaction in laboratory systems

[DOI] [PMC free article] [PubMed] [Google Scholar] 67.McReynolds M.R., Chellappa K., Chiles E., Jankowski C., Shen Y., Chen L., Descamps H.C., Mukherjee S., Bhat Y.R., Lingala S.R., et al

Conclusion The metabolic reprogramming in NSCLC presents both challenges and opportunities for therapeutic intervention