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Peptide degradation accelerates after 28 days even under proper refrigeration at 28C, resulting in progressive loss of bioactivity due to oxidation and hydrolysis of peptide bonds

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Elevated ROS levels can lead to mitochondrial DNA damage, enzyme inhibition, and cellular dysfunction, ultimately contributing to disease progression (Sharifi-Rad et al., 2020)

In a study on LGI1 encephalitis by Rodriguez A et al., corticosteroids were used in at least 90% of patients, with most showing improvement, and the results also suggested that acute treatment with corticosteroids may be more effective than IVIg in improving acute outcomes [10]