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These changes can result in a reduction of the amount of capillaries that supply the heart with blood, as well as fibrosis, chemical changes, and changes in the metabolism and organization of heart cells

Reduced glutathione is the active form that neutralizes free radicals, while oxidized glutathione occurs when GSH loses an electron after combating oxidative stress

In the previous article, we have repeatedly mentioned the role of ncRNA in IBD and related CRC progression (Liang et al., 2019

Overall, this work provided a cascade-enhanced nanocatalytic strategy against hypoxic tumor by integrating respiration inhibition, GSH depletion and targeted delivery for effective starving-chemodynamic therapy