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Insulin-like growth factor-1 and lipid metabolism IGF-1 promotes preadipocyte differentiation [181], however, as preadipocytes differentiate, they stop expressing IGF-1Rs, delegating such functions now to insulin receptors, which increase in number significantly

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Documentation should support an acute injury mechanism , along with clinical findings such as muscle tenderness and reduced range of motion when present

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Nerve conduction studies or electromyography are generally reserved for atypical presentations (such as marked asymmetry, predominant motor involvement, or rapid progression), diagnostic uncertainty, or when other causes are suspected