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SKU: 23396504834 · From ldesquadrias.com.br

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Sustained pharmacological inhibition of PKC protects against hypertensive encephalopathy through prevention of bloodbrain barrier breakdown in rats

[Abstract] Cancer Biol Ther

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Interestingly, recent studies indicate that in the setting of ATII-induced hypertension, a downregulation of the dihydrofolate reductase was observed, which was accompanied by decreased vascular BH 4 levels and an uncoupled eNOS, 91 implicating a potential role of this salvage pathway in the development of hypertension