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CBS, a heme protein, is active in the oxidized form, whereas methionine synthase is inactivated by oxidation and requires reductive methylation for reactivity (Chen and Banerjee, 1998

However, the story is much more complex and interesting and the last decade has witnessed a seismic shift in our level of knowledge about the pharmacological mechanisms and clinical benefits that are offered by the phytocannabinoids present in Cannabis sativa