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This is the IDO metabolic trap, where cells are trapped in an abnormal state as IDO1 stops making kynurenine and tryptophan levels remain high

The Emotional toll on pet owners theme (section 3.5.5) was poignant as pet owners caring for chronically ill pets often describe the emotional burnout and sadness involved in managing chronic illness in their pets, especially when treatments are not effective. 4.8 Implications for veterinary professionals and pharmaceutical companies Studies by Lavan et al