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H., Copeland, W

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N was joined to the C-terminus of the elastin-like polypeptide (ELP) via a flexible linker ELP-N (construct 5), and mutant C* was fused to the N-terminus of various sample target proteins C*-POI (construct 3, 6-10)

The primary analysis was conducted using the Inverse Variance Weighted (IVW) method, and was further corroborated by an array of statistical techniques including MR-Egger, Weighted Median, Weighted Mode, cML-MA, ConMix, MR-RAPS, and DIVW to ensure robustness and reliability of the findings.Heterogeneity was evaluated using Cochrans Q test, horizontal pleiotropy was assessed through MR-Egger regression, and leave-one-out analyses were performed to validate the causal relationships

[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Soubeyrand E., Kelly M., Keene S.A., Bernert A.C., Latimer S., Johnson T.S., Elowsky C., Colquhoun T.A., Block A.K., Basset G.J