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elegans have uncovered genetically conserved roles of LD in embryonic integrity (25,107,108), mammalian systems exhibit additional layers of complexity, particularly in steroidogenesis and hormonal regulation

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Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling

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They concluded that, "the finding of higher serum 5HT concentrations in dogs predisposed to MMVD (CKCS) and dogs with mild MMVD suggests that alterations in 5HT signaling might play a role in progression of early stages of MMVD." In a 2009 study, some of the same researchers found, "Dogs with DMVD had significantly higher serum 5HT concentrations when compared with large breed control dogs