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Isolation and purification of Baicalein, Wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography

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In our study, as the intracellular -GC level was only increased slightly compared with that of original strain W303-1b when F pathway was introduced, we artificially introduced a flexible six-glycine linker between the two enzymes of G pathway as well as P pathway to improve the coupling efficiency by mimicking the native domain fusion of GshF