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Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages

A.JouroukhinY.ChewJ.VidenskyS.FarahM

doi: 10.1210/er.2009-0013 42 ItoKYamamuraSEssilfie-QuayeSCosioBItoMBarnesPJet al

In doing so, they repair mitochondrial damage, restore energy metabolism, remove excess reactive oxygen species (ROS), and interrupt inflammatory cascades, offering a novel therapeutic approach

[DOI] [PMC free article] [PubMed] [Google Scholar] 145.Cohen M.H., Shen Y.L., Keegan P., Pazdur R

What made AOD 9604 compelling was the identification that a specific region of the hGH molecule, the C-terminal fragment, was responsible for this fat-burning effect, and that this region operated through a pathway separate from the growth hormone receptor