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The treatment involves using a device with fine needles to create micro-injuries in the skin, while simultaneously delivering RF energy into the deeper layers of the skin

This time-temperature relationship is why the FDA gives a specific number of days (21) at a specific maximum temperature (86 degrees Fahrenheit) rather than just a temperature limit

Gustin et al., 1998)

doi: 10.1016/j.phrs.2019.104454 55 MeijnikmanASDavidsMHerremaHAydinOTremaroliVRios-MoralesMet al

Although dopamine has been the neurotransmitter of focus, there are downstream effects on other neurotransmitters such as GABA and glutamate

The dosage form of this injection is a liquid, and it should be stored in a dry place