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This approval represents the first FDA-approved drug specifically targeting mitochondrial function, establishing regulatory precedent for the mitochondrial dysfunction pathway in aging and neurodegeneration

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Acknowledgements We acknowledge co-funding from the Fondazione per la Ricerca Biomedica Saverio e Isabella Cianciola and from Next Generation EU, in the context of the National Recovery and Resilience Plan, Investment PE8 Project Age-It: Ageing Well in an Ageing Society

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It should be emphasized that exceeding the cutoff weight loss of 15 Percentage is of great clinical importance

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For example, Liu and collaborators observed similar effects to those described in HCC, but in pancreatic cancer cells (Liu et al., 2018 [19])

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