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Mutagenicity and human chromosomal effect of stevioside, a sweetener from Stevia rebaudiana Bertoni

Deficiencies can be easily prevented with proper supplementation

We used iNap1 and monitored dynamic changes in NADPH metabolism in primary cultured ECs

There is no core pathogenome to distinguish carriage from invasive N

Keywords Viticis Fructus Phytochemistry Pharmacology Pharmacokinetics Comprehensive applications AUC (0-t) Area under the plasma concentrationtime curve Bax Bcl-2 associated X protein Bcl-2 B cell lymphoma-2 protein Bcl-xL B-cell lymphoma extra-large Bim Bcl-2 interacting mediator of cell death Caspase-3 Cysteinyl aspartate specific proteinase-3 CD Circular dichroism ChP Pharmacopoeia of the Peoples Republic of China C max Maximum drug concentration in plasma CNKI China National Knowledge Infrastructure COSY Correlation spectroscopy CRC Colorectal cancer CYR61 Cysteine-rich61 DR5 Death receptor 5 ERK Extracellular regulated protein kinases FOXM1 Forkhead box protein M1 FOXO3a Forkhead box O3 GABA -amino butyric acid GCGCMS Comprehensive two-dimensional gas chromatography hyphenated with mass spectrometry HCC Hepatocellular carcinoma HDL High-density lipoprotein HRESIMS High-resolution electrospray ionization mass spectroscopy HRFABMS High-resolution fast atom bombardment mass spectrum KOA Knee osteoarthritis LC/MS Liquid chromatography/mass spectrometry LCSLCs Lung cancer stem-like cells LDL Low density lipoprotein LD 50 median lethal dose MAPK Mitogen-activated protein kinase MMP-1 Matrix metalloproteinase-1 MMP-2 Matrix metalloproteinase-2 MMP-9 Matrix metalloproteinase-9 NF-B Nuclear factor kappa-B NIR Near Infrared NLRP3 Nucleotide oligomerization domain-like receptor protein 3 NMR Nuclear magnetic resonance NO Nitric Oxide NOESY Nuclear overhauser effect spectroscopy NPC Nasopharyngeal carcinoma PI3K/AKT Phosphatidylinositol 3-kinase/protein kinase B PKR Protein kinase R PMS Premenstrual syndrome PPY Pyranopyran-1,8-dione ROS Reactive oxygen species IL-1 Interleukin-1 IL-6 Interleukin-6 IR Infrared ray SCTF Shrub Chaste Tree Fruits TCMs Traditional Chinese medicines T max The time to reach maximum drug concentration TNF- Tumor necrosis factor- UC Ulcerative colitis HPLC-DAD High-performance liquid chromatography coupled with a diode array detector ISSR Inter simple sequence repeat ITS2 Internal transcribed spacer 2 JNK c-Jun N-terminal kinase K2P Kimura 2-Parameter UHPLC-Q-Orbitrap HRMS Ultra-high-performance-liquid chromatography-quadrupole-Orbitrap high resolution mass spectrometry UHPLC-MS Ultra-High performance liquid chromatography-mass spectrometry UV Ultraviolet

doi: 10.1111/bph.13936