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Vasoactive intestinal peptide: cardiovascular effects

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Nathan P, Zweifel M, Padhani AR, Koh DM, Ng M, Collins DJ, Harris A, Carden C, Smythe J, Fisher N: Phase I trial of combretastatin A4 phosphate (CA4P) in combination with bevacizumab in patients with advanced cancer

This dose selection was informed by the Phase 2 observation that the 36 mg and 45 mg doses showed only modestly different efficacy but the 45 mg dose carried higher rates of gastrointestinal adverse events

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(III) immune ignorance type, where tumor mutation burden and the expression of antigen presentation machinery marker are low [24]