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ME1 and ME3 require NADP + and ME2 utilizes either NAD + or NADP + for their catalytic activities, thus NADPH can be produced by ME both directly and indirectly through the activity of the NNT that catalyzes the transfer of hydride ions from NADH to NADP + and produces NADPH in mitochondria

Today we will explore why carbidopa/levodopa may cause Vitamin B6, as well as Vitamin B12 deficiency, what the potential consequences are, and what can be done to correct the problem