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Materials and methods Retrieval of GPX and APX genes/proteins Eight Arabidopsis GPX reference protein sequences such as GPX1 (P52032.2), GPX2 (O04922.1), GPX3 (O22850.1), GPX4 (Q8L910.1), GPX5 (Q9LYB4.1), GPX6 (O48646.2), GPX7 (Q9SZ54.2), and GPX8 (Q8LBU2.1), as well as and eight Arabidopsis APX reference sequences such as APX1 (Q05431.2), APX2 (Q1PER6.3), APX3 (Q42564.1), APX4 (P82281.2), APX5 (Q7XZP5.2), APX6 (Q8GY91.1), APXT (Q42593.2), and APXS (Q42592.2) were obtained from UniProtKB/Swiss-Prot database of NCBI (Romiti, 2006)

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Mitochondrial cascade hypothesis: Mitochondrial dysfunction and the accumulation of reactive oxygen species lead to neuronal damage and ultimately contribute to the pathogenesis of neurodegenerative diseases, particularly AD

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