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Patient-centred strategies must identify patients tumour, current and planned conventional therapies (chemotherapy, endocrine therapy, targeted therapy and immunotherapy), comorbidities, organ function, nutrition profile, dietary habits and existing medication or supplement use since these factors critically impact both the efficacy and safety of supplementary approaches (236)

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Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism

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[9] Administration is contraindicated in patients with known hypersensitivity to zinc salts or any component of the formulation and in those with severe brittle anemia where additional zinc could impede copper utilization, as noted in labeling