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Ethics statement The studies involving human participants were reviewed and approved by the local ethics committee in Stockholm (2016/1485-32, amendment 2017/779-32)

All published rodent metabolic studies used subcutaneous injection as the exclusive route

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doi: 10.1038/emi.2017.54 117 BurbeloPDKellerJWagnerJKlimaviczJSBayatARhodesCSet al

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In addition, PLGA allows surface modifications (e.g., aptamers, antibodies, hyaluronic acid), enabling tumor-specific accumulation and reduced systemic side effects key for chemo resistant metastatic CRC cases