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Public Health 19 , 10189 (2022)

(2012), 9cRA was repeatedly administered through the intra-nasal route as intracerebral delivery is not feasible for repeated drug administration and may require chronic cannulation, whereas small molecules bypass the bloodbrain barrier and reach brain parenchyma non-invasively if delivered via the intranasal route

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This means that the synapse mitochondria have additional functions at the nerve terminals, which may include Ca 2+ buffering directly affecting the firing probability of neurons [37, 38]

& Ashong, D