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Currently, loss of immune tolerance, caused by the combined action of environmental and genetic factors, is regarded as a primary risk factor for developing RA [3, 4]

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Fourteen reported subjective improvement, but there was no control group, no blinded assessment, no objective functional endpoint and no follow-up imaging endpoint [5]

Subsequent reperfusion, although essential for tissue survival, paradoxically exacerbates renal injury through oxidative stress, inflammatory activation, and microvascular dysfunction (Mehta et al

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77,78 Conclusion In conclusion, hydrogen is a gas molecule with significant biological activity, and its administration is a promising treatment option widely applied in disease prevention and the treatment of various systems, with no obvious toxic side effects observed