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2.4 Genetic, epigenetic, and molecular alterations Genetic factors contribute to endometriosis-associated infertility, with studies highlighting polymorphisms in antioxidant enzyme genes

Dikalova AE, Gongora MC, Harrison DG, Lambeth JD, Dikalov S, Griendling KK

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Hepatic enzyme activity varies with genetic polymorphisms (CYP3A4*1B alleles, for example, alter metabolic capacity)

For instance, the cholesterol biosynthesis pathway is downregulated in MS and in astrocytes in the poorly remyelinating model EAE 119 , and single nuclei sequencing of chronic active MS lesions indicate altered lipid storage/response genes in microglia and astrocytes 47