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Long-term effects beyond 52 weeks in clinical use are still under study

Delivered intravenously, it bypasses the digestive system to provide higher bioavailability and faster cellular effects

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In a seminal study on HepG2 human liver cells exposed to arsenite or arsenate, synchrotron microprobe XRF combined with X-ray absorption near-edge spectroscopy (XANES) and extended X-ray absorption fine structure (EXAFS) mapped As accumulation in the euchromatin region of the nucleus predominantly as As-tris-sulfur species, implicating interactions with nuclear proteins (rather than direct DNA binding) as a key mechanism of As-induced toxicity [1]