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4D, left+mid) and increased mitochondria-dependent energy production (Fig

Most (64%) indicated they would be more likely to engage if the education was accredited

270 In addition, aged HSCs accumulate gene mutations, and HSC clones carrying these mutations gradually dominate hematopoiesis owing to their proliferative advantages, forming clonal hematopoiesis, which is the most important precursor lesion of myeloid malignancies

Together, these counteractions could obviously suggest an alternative common pathway

Based on the p53 regulatory network, small molecule modulators or gene editing tools can be designed, and their therapeutic effects on cartilage protection and inflammation alleviation can be validated in OA animal models

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