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Novel roles for biogenic monoamines: from monoamines in transglutaminase-mediated post-translational protein modification to monoaminylation deregulation diseases

Through chemogenetic activation of astrocytes calcium activity in the BF, astrocytes decreased the consolidation of NREM sleep by amplifying the activation of the GABAergic neurons, which are more active during wakefulness than during sleep (Hassani et al., 2009), increasing persistent inhibition in the BF neural network

Indeed, this aldehyde is more abundant in the human body than previously thought

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The resulting cells were harvested through centrifugation at 800 rpm for 5 min and then washed twice with ice-cold phosphate-buffered saline (PBS)

The wide range of CP dosages used in models, some exceeding clinically relevant exposures, further complicates relevance to patient care